With the tropical climate and unstable land forms, coupled with high population density, poverty, illiteracy and lack of adequate infrastructure, India is one of the most vulnerable developing countries to suffer very often from various natural disasters, which strikes causing devastating impact on human life, economy and environment. Though it is almost impossible to fully recoup the damaged caused by the disaster it is possible to minimize potential risks by developing early warning strategies. “Efficient management of Disasters, rather than mere response to their occurrence has, in recent times, received increased attention both within India and abroad.” Hospitals play a key role in Management of the affected population by providing immediate and effective treatment at the site and in the hospital. Considering the wide range of disasters and no bar for time, place and people it requires immediate intervention, and this management would be an extension of emergency or casualty services of hospital. It adds an extra load to hospital, functions, and to cope up this situation it requires to have a systematic, planned and effective approach. In this article, I have discussed a model disaster management plan for a hospital, clinical principles of management of casualties and specific problems of Disaster Management. A guide line for operational framework to face disaster in the form of Disaster manual is suggested for each hospital. A preplanned disaster management plan according to this guideline would provide an edge to a hospital in such crucial situations and in turn will serve the humanity & society.