Objective: In order to primary prevention in cardiovascurlar diseases to establish the relationship lipid peroxidation (Malon De Aldehide) and antioxidation capacity with posttraumatic stress disorder (PTSD). Method: MalonDeAldehide and antioxidation capacity in 30 case of PTSD were compared with 30 normals in ISFHAN Cardiovascular Research Center, using Symptoms check List 90 revised (SCL 90 R) to determine Global Symptom Index and using laboratory tests to measure MDA and antioxidation capacity. Results: The mean of GSI for cases was 2.13 and for controls was 0.41 (p < 0.05). MDA level was higher for cases (0.822 microgramg/DL in cases, 0.634 micorgramg/DL in normals, p < 0.05) while peroxidation capacity was higher for control group group (20.04% glubular hemolysis in controls, 13.16% in cases, p < 0.05). Conclusion: Lipid peroxidation and antioxication capacity as an index for primary prevention in cardiovascular and metabolic diseases, and aging process have relation with PTSD, and may be viewed as risk factor for PTSD. Imipermain and other antioxidatants were recommended for PTSD to reduce lipid peroxidation.