The purpose of this study was to measure leptin, glucose and insulin concentration in the blood of patients during ST elevation acute myocardial infarction and to compare them with values obtained from normal subjects. Leptin concentration was measured in 31 menopause Jordanian women patients (50-72 years of age) with acute myocardial infarction and 19 normal menopause women (49-64 years of age). Leptin concentration were measured using two sites immunoradiometric assay (IRMA) principle. In normal (N = 19) leptin concentration was 15.5±5.4 ng mL-1 (Mean±SD). While, in patients with acute myocardial infarction was 22.9±5.7 ng mL-1 (Mean±SD). Data showed significant difference in both groups (p = 0.000). In addition insulin concentrations were significantly increased in patients with acute myocardial infarction (74.2±10.8 vs. 38.8±14.5 pmol L-1, p = 0.000) compared to the control group. Glucose concentrations were lower in patients with acute myocardial infarction (107.5±7.2 vs. 166.9±11.7 mg dL-1, p = 0.000) compared to the normal group. Also, both total cholesterol and triglyceride were significantly higher in patients with acute myocardial infarction compared to the control group. It was comcluded that leptin, insulin, cholesterol and triglyceride concentrations were significantly higher and glucose level was significantly lower in patients with acute ST elevation myocardial infarction compared to normal group.