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MYOCARDIAL INFARCTION WITH ITS RELATION TO ASCORBIC ACID

Keywords: Myocardial infarction , ascorbic acid , Mass Index.

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Abstract:

The present study includes a total 66 patients with acute myocardial infarction and 66 age group and sex matched healthy controls. 53 (80.3%) were males and 13 (19.7%) were females. Mean age in patients was 51.76±11.1 and maximum patients were in the age group 40-60 years (75.76%). Mean plasma ascorbic acid in patients (0.37±0.064 mg/dL) was lower than controls (0.58±0.16 mg/dL). 50 (75.76%) patients had plasma ascorbic acid 0.4mg/dL as compared to 5 (7.58%) controls. Low plasma ascorbic acid ( 0.4 mg/dL), hypercholesterolemia ( 200 mg/dL), increased triglycerides ( 150 mg/dL), decreased HDL (<40 mg/dL), increased LDL ( 130 mg/dL) and smoking were significantly associated with acute myocardial infarction. Mean plasma ascorbic acid was significantly lower in males, diabetics, hypercholesterolemic 200 mg/dL, serum triglycerides 150 mg/dL, serum HDL <40 mg/dL, serum LDL 130 mg/dL, body mass index 25 Kg/m2, smoking and history of alcohol intake. Plasma ascorbic acid was significantly lower in cases (n=9) 0.36±0.07 mg/dL) than controls (n=17) (0.72±0.12 mg/dL) without any conventional risk factors (p<0.001). AWMI occurred in 37 (56.06%), IWMI in 27 (40.91%), AWMI+IWMI in 2 (3.03) patients. Mean plasma ascorbic acid was 0.31±0.04 mg/dL, 0.35±0.05 mg/dL, 0.41±0.07 in patients with AWMI+IWMI, AWMI and IWMI respectively. Total of 19 patients died during 1 month follow-up. On admission 50 patients had plasma ascorbic acid 0.40 mg/dL and 16 had >0.40 mg/dL. A total of 8 patients died within one week in hospital, among them 7 had plasma ascorbic acid 0.04 mg/dL and 1 had plasma ascorbic acid >0.4 mg/dL. At one week 23 patients had plasma 0.04 mg/dL and 35 had >0.4 mg/dL. A total of 7 patients died in 2nd and 3rd week, among them 5 had plasma ascorbic 0.40 mg/dL and 2 had plasma ascorbic acid >0.40 mg/dL. At 3 weeks, 8 patients had plasma ascorbic acid 0.40 mg/dL and 40 had >0.40 mg/dL. A total of 4 patients died and among them 3 had plasma ascorbic 0.40 mg/dL and 1 had plasma ascorbic acid >0.04 mg/dL. The association was significant (p<0.01) with a relative risk of 15.2 and attributable risk of 93.42% indicating mortality was significantly associated in patients in whom plasma ascorbic acid remained persistently low i.e. 0.40 mg/dL. The mean plasma ascorbic acid was 0.37±0.06 mg/dL, 0.44±0.08 mg/dL, and 0.50±0.09 mg/dL on admission, at one week and after 3 weeks respectively.

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