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USE OF LIPOSOMES AND NANOPARTICLES FOR BRAIN DRUG TARGETING

Keywords: Liposome , Nanoparticle , Phospholipid , PEG Polymer , Blood Brain Barrier , Drug targeting , CNS.

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Abstract:

The Blood Brain Barrier (BBB) poses a obstacle for a drugs, including antineoplastic agent, antibiotics, neuropeptides, CNS active agents, to be delivered to the brain for therapeutic reasons. The use of formulation dependent strategy such as the use of heterogenous pharmaceutical systems for its effective targeting to the brain is being explored recently. Liposomes and Nanoparticles are good possibilities to achieve the goal. Chemically modified liposomes and nanoparticles are tried in recent times to act as brain targeting aids, and this article tries to explain the possibilities and problems behind such an endeavor.KEY WORDS:

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