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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME N-METHYLATED DERIVATIVES OF THIAZOLYLAMINO ACIDS AND PEPTIDES

Keywords: Solution Phase Technique , Thiazole , Linear Peptides , Anthelmintic , Insecticidal.

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Abstract:

A series of substituted thiazole containing N-methylated amino acids and peptides were synthesized by solution phase technique and were subjected to evaluation of biological activities. In this project 2-amino-4-phenylthiazole is synthesized and then coupled with protected amino acid. In case of dipeptide, protected amino acids are condensed together to get dipeptide using DIPC ( di-isopropylcarbodiimide) and then dipeptide is condensed to 2-amino-4-phenyl thiazole using coupling agent to get the final compound. Synthesized compounds are characterized and anthelmintic and insecticidal activity studies were performed.

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