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SYNTHESIS OF 4-[(4)5- IMIDAZOLYL] BENZOYL DERIVATIVES OF AMINO ACIDS AND PEPTIDES AS POTENT ANTHELMINTIC AGENTS

Keywords: Benzimidazole , Peptides , solution phase peptide synthesis , anthelmintic activity and insecticidal activity.

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Abstract:

A series of 4-[(4)5-imidazolyl] benzoic acids derivatives of amino acids and peptides were synthesized by reacting 4-[(4)5-imidazoyl benzoic acid with amino acids and dipeptides. The structures of the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR, and GC-MS data and the synthesized compounds were screened for their anthelmintic activity and the results showed that the compounds containing Ala-Ile and Pro-Val exhibited potent anthelmintic activity against Eudrillus Eugenia at that of standard Mebendazole a concentration of 100mg/50ml. The synthesized compounds were also studied for their insecticidal activity and they showed moderate to less insecticidal activity as compared to the standard drug Chloropyrifos.

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