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Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation

DOI: 10.4236/anp.2013.21010, PP. 51-59

Keywords: Curcumin, Nanocrystal, Dissolution Evaluation

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Abstract:

Curcumin is the main biologically active phytochemical compound of turmeric that has been widely used by ancient cultures throughout Asia. However the dissolution rate limited absorption and pre-absorption degradation limits its use as a potential therapeutic. In this study an attempt has been made to overcome the above limitations by curcumin delivery through nanotechnology. Nanocurcumin solid dosage formulations were prepared and studied for its dissolution behaviour. Considerable improvement in the dissolution behavior was observed in the drug nanocrystal-loaded solid dosage forms. This is expected to enhance the bioavailability of poorly soluble medicinal herbs such as turmeric in the body.

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