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Tumores neuroendócrinos gástricos e duodenal simultaneos Simultaneous gastric and duodenal neuroendocrine tumors

Keywords: Tumores neuroendócrinos , Anemia perniciosa , Gastrite atrófica , Gastrina , Neuroendocrine tumors , Atrophic gastritis , Pernicious anemia , Gastrin

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Abstract:

Os tumores neuroendócrinos gastrointestinais s o neoplasias raras. A probabilidade de ocorrência simultanea de tumores neuroendócrinos gástricos e duodenal é baixa. Os autores descrevem o caso de um doente do sexo masculino, 73 anos, com diagnóstico de anemia perniciosa desde há 13 anos, submetido a endoscopia digestiva alta por vigilancia. O exame revelou mucosa do corpo gástrico com aspecto atrófi co com pequenas pápulas e um pólipo séssil no bulbo duodenal. O exame histopatológico mostrou tratar-se de microtumores neuroendócrinos gástricos no contexto de gastrite atrófi ca e um tumor neuroendócrino no bulbo duodenal. Os autores discutem a ocorrência simultanea de tumores neuroendócrinos gástricos e duodenal, no contexto de doente com anemia perniciosa, abordando o mecanismo etiopatogénico, estratégia de tratamento e prognóstico destas patologias Gastrointestinal neuroendocrine tumors are relatively rare neoplasms and usually occur singly. The probability of simultaneous occurrence of gastric and duodenal carcinoid tumors is low. The authors report a case of a 73-year old male patient, diagnosed pernicious anemia 13 years ago, who underwent upper endoscopy for surveillance. The examination revealed atrophic gastritis and a polypoid lesion in the duodenal bulb, which was completely excised. Pathological examination revealed gastric microcarcinoids in the context of atrophic gastritis and a neuroendocrine tumor in the duodenal bulb. The authors discuss the simultaneous occurrence of gastric carcinoid tumors and duodenal, in the context of pernicious anemia, addressing the etiopathogenic mechanism, treatment strategy and prognosis of these diseases

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