A REVIEW ON ATRIGEL DRUG DELIVERY SYSTEM

Atrigel system is a proven sustained-release drug delivery platform that delivers therapeutic levels of a wide spectrum of drugs over a few days to several months with a single injection. Atrigel system is use for both parenteral and site-specific drug delivery. The ease of manufacture of the Atrigel system and its relatively pain-free subcutaneous injection into the body provide significant advantages over both solid implants and microparticles. Most of the standard biodegradable polymers can be used in the Atrigel technology. The hydrophilic solvents employed in the Atrigel system to dissolve the polymers. The low-molecular-weight polymers at low polymer concentrations can be easily injected into the body using standard needles. The high molecular- weight polymers at high polymer concentrations may be used as gels or putties that can be placed into sites in the body where they solidify and provide support. Atrigel technology provides a more stable, ready-to-use formulation.