Since 2004, the Cicrp: “Centre Interrégional de Conservation et Restauration du Patrimoine”, located in Marseilles has been involved in an interdisciplinary research program dealing with infestation and re-infestation, on lining pastes used in painting conservation, by the Stegobium paniceum through a GIS system : a geographical information system called “StegoGIS”. The GIS helps understand the insects ethology in its environmental context, mainly in flour and semolina millings in order to determine analysis criteria to prevent, mitigate and fight infestation in the cultural property environment. Our approach is based on three main lines: 1- A transverse approach of infestation in any type of cultural heritage institution: archives, libraries, museums, historic buildings where organic material collections and environment are attractive on an “insect point of view”. 2 –An IPM strategy (Integrated Pest Management) including conservation and management of collections and buildings also based on an infestation survey with actual or potential risks. 3- A “decision- making tool” in diagnosis, preventing methods and treatments for professional conservation staff.