Variously substituted thiazoles derivatives showed wide range of biological activity. The computational evaluation of the substituted thiazole containing derivatives as SYK inhibitor was performed. By using online servers applying different approaches the Tyrosine protein kinase (SYK) was identified as target for variously substituted thiazole containing derivatives. The molecular descriptor analysis was performed to identify drug likeness of the thiazole derivatives by Lipinski’s rule of five. Then docking analysis was performed by PyRx software using AutoDock vina 4. Derivatives showed comparatively significant binding energy value followed Lipinski’s rule. The study provides the base for further in vitro and in vivo study of substituted azoles containing compounds as SYK inhibitor and proposed drug to be used for allergic diseases.