Natural products are the source of drug leads from time immemorial. Therapeutically interesting and important drugs has been developed from plant source which are being used in traditional system of medicine. One such plant is Gisekia pharnaceoides Linn. being used in the traditional system for curing various diseases. This review presents the information about Gisekia pharnaceoides (Molluginaceae) and the article includes the ethno botanical, ethno pharmacological, pharmacognostical, phytochemical and pharmacological reviews. The profile presented in this review might be a source for researchers as well as practitioners in their future study.