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ANITIDIABETIC, ANTIHYPERLIPIDAEMIC AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACT OF FERONIA ELEPHANTUM CORREA LEAF AND BARK IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS

Keywords: Feronia elephantum , antihyperlipidaemic , antioxidant , blood glucose , diabetes mellitus , alloxan induced diabetic rats.

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Abstract:

The aim of the present study was to evaluate the antidiabetic Potential of ethanol extract of Feronia elephantum Correa leaf and bark in normal and alloxan induced diabetic rats. Diabetes was induced in Albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of F. elephantum leaf and bark at a dose of 400mg/kg of body weight was administered separately at a single dose per day to diabetes induced rats for a period of 14 days. The effect of ethanol extract of F. elephantum leaf and bark on blood glucose, serum lipid profile, the levels of lipid peroxides and antioxidant enzymes, such as catalase, superoxide dismutase, glutathione peroxidase and reduced glutathione were examined. Oral administration of F. elephantum leaf and bark extract to diabetic rats for 14 days significantly reduced the levels of blood glucose, lipid parameters except HDL-C and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes. Ethanol extract of F. elephantum supplementation is useful in controlling the blood glucose level, improves the plasma insulin and lipid metabolism. It is beneficial in preventing diabetic complication from lipid peroxidation and antioxidant system in experimental diabetic rats; therefore, it could be useful for prevention or early treatment of diabetes mellitus.

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