The quality of a pharmaceutical product is essential to ensure the safety of the patients. Different parameters of quality control of pharmaceutical products can guarantee the quality and bioavailability and optimal therapeutic activity. Therefore, the present study was undertaken with the aim of assuring the quality and the therapeutic activity of ibuprofen tablets available in the Bangladeshi drug market. Different quality control parameters, i.e., the variation of weight, friability, content uniformity, disintegration time and dissolution profiles were assessed in vitro. To demonstrate the differences between the products, the difference (f1) and similarity (f2) data were analyzed. The results showed that all products fulfill the given specification selected by Pharmacopeia (USP-NF).