Infertility as a medical and social problem has acquired global dimensions and its incidence is supposed to be gradually increasing by every decade. Despite great advances made by medical science in understanding each stage of the reproductive process, the problems that occur at each step and planning their management, some arenas post lacunae, due to which infertility is still a catastrophe. One such arena is the role of Oligozoospermia in male infertility and its management. The present study was undertaken to understand the role of Apatyakara Ghrita (an Ayurvedic formulation) in male infertility i.e. Oligozoospermia. Individuals (N = 20), whose semen sample was having low sperm count < 20 millions/ml and motility < 50% SLP, < 25% RLP (WHO1992) were selected from the O.P.D. The selected patients were given Apatyakara Ghrita - 10 g twice a day with lukewarm milk for 90 days. After analyzing semen reports before and after treatment, suggested a definite role of Apatyakara Ghrita to treat infertility related with oligozoospermia. Treatment resulted 71.14% increase in sperm count which is statistically highly significant [p<0.001], improved level motility by 79.05% [p<0.001] and improved overall semen quality in a significant number of individuals. There was an increase in sexual desire by 87.87% in patient which is statistically shows highly significant results. The penile erectile function was improved by 71.79% [p<0.001] in registered patient which shows highly significant results. There was 23.08% relief in Night emission and post act exhaustion was improved by 43.10%. There is relief of 54.54% in dyspnoea on effort and 60.52% [p<0.001] in pain after and during coitus which statistically highly significant.