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p-ANCA and c-ANCA frequency and their relationship with other diseases in patients with lung cancer

Keywords: p-ANCA , c-ANCA , paraneoplastic syndrome , lung cancer

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Objectives: In this study, we aimed to investigate the association of cancer with vasculitis and the frequency of cancer-related paraneoplastic syndromes and their relationship by measuring blood levels of Perinuclear type Anti-Neutrophilic Cytoplasmic Antibody (p-ANCA) and Cytoplasmic type antineutrophil cytoplasmic antibodies (c-ANCA) in patients with lung cancer and asthma and in healthy individuals.Materials and methods: 20 patients diagnosed with asthma, 26 patients following up with a diagnosis of lung cancer and control group of 20 healthy individuals were enrolled in this study. ANCA levels were measured in blood samples.Results: Borderline positive c-ANCA detected in 1 of 26 patients and 1/32 percent were positive detected in one patient. Borderline positive p-ANCA detected in 1 of 26 patients and 1/32 percent were positive detected in 1 patient. p-ANCA was positive detected in 2/20 of asthmatic patient and c-ANCA was borderline positive detected in 1/20 asthma patient. In asthma and cancer patients, physical examinations and pathological findings did not support the vasculitis. Only one subject in the control group was found to be borderline positive for c-ANCA.Conclusion: As a result, in some of the patients the positivity of ANCA was detected not related with vasculitis and paraneoplastic findings. Because of this, vasculitis should be considered in differential diagnosis of the patients whom considered as malignancy. J Clin Exp Invest 2011; 2 (4): 384-387Key words: p-ANCA, c-ANCA, paraneoplastic syndrome, lung cancer


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