In Ayurveda, Mental disorders and psychological temperaments have been broadly described [e.g. vata vyadhi (nervous disorders), unmada (insanity), murccha, moha (loss of consciousness), vismriti (amnesia), apasmara (epilepsy) etc.]. In Ayurveda, Apasmara (or epilepsy) has been described among the maharoga (a group of eight diseases well-known for causing serious morbidity). In the Ayurvedic texts, Apasmara (Epilepsy) is defined as sudden abhorrent bodily activities (vibhatsa-cheshta) accompanied by momentary blackouts or loss of consciousness (tama-pravesha) owing to disturbance in mental faculties of dhi (intelligence), dhriti (retention) and smriti (memory). Epilepsy is a major public health problem all over world. The estimated proportion of the general population with active epilepsy (i.e. continuing seizures or the need for treatment) at a given time ranges from 4-10 per 1,000 people. Herbal remedies have been recommended in various medical treatises for the cure of different diseases. In this regard, there is great prospective for identifying excellent Ayurvedic components or its active principles, particularly in consideration of the fact that such substances may provide maximum advantage with cost effectiveness, least side effects, and improvement of patient compliance.