The methanolic extract of leaves of Ficus arnottiana was used to evaluate the analgesic activity. The above activity was evaluated using the eddy’s hot plate and heat conduction method and acetic acid induced writing in mice. The dose used for the test of activity (100, 200. 400 mg/kg i.p). The extract at all doses tested significantly (P<0.001) inhibited acetic acid induced writhing and also significantly (P<0.05) prolonged the reaction latency to pain thermally induced in mice by the hot plate. The phytochemical screening revealed the presence of alkaloids, flavonoids, glycosides, saponins and tannins which might be responsible for the observed analgesic and anti-inflammatory activity. This study showed that Ficus arnottiana possesses significant anti-inflammatory and analgesic properties in rodents which supported the folkloric claim for the use of the plant as medicine.