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HEPATOPROTECTIVE ACTIVITY OF POLYCARPEA CORYMBOSA

Keywords: Polycarpea corymbosa , CCl4. Serum marker enzymes.

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Abstract:

Aim of study: To evaluate the hepatoprotective activity of Polycarpea corymbosa whole plantextract against carbon tetra chloride (CCl4) –induced hepatotoxicity.Material and methods: Hepatotoxicity was induced in male wistar rats by administration of CCl4(1.25ml/kg/day for 7days). Methanolic extract of whole plant of Polycarpea corymbosa wereadministered to the experimental animals (20 mg/kg/day,p.o.for 7 days). The hepatoprotective effectof these extract was evaluated by the assay of liver function biochemical parameters (alanineaminotranferse, aspartte aminotranferse and alkaline aminotranferse) and histopathological studies ofthe liver.Results and Discussion: In methanol extract-treated animals, the toxic effect of CCl4 as controlledsignificantly by restoration of the levels of enzymes levels as compared to the normal and thestandard drug silymarin-treated groups. Histology of the liver section of the animals treated with theextract showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration, whichfurther support the hepatoprotective activity.Conclusion: Methanol extract of the whole plant of P. corymbosa possesses significanthepatoprotective acivity.

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