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Future Drugs for Treatment of Acute Respiratory Distress Syndrome

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Abstract:

The acute respiratory distress syndrome (ARDS) is a common clinical disorder characterized by injury to the alveolar epithelial and endothelial barriers of the lung, acute inflammation and pro rich pulmonary edema leading to acute respiratory failure. Knowledge of the pathophysiology and management of ARDS has been improved immensely since its original description. But pharmacotherapies have not been hopeful in treatment of ARDS in clinical trials. Mortality from ARDS has decreased in certain centers over the last 10 years due to advances in supporting critically ill patients. This trend may open the window of opportunity for pharmacological manipulation of ARDS. This study reviews conventional and new treatment challenges like use of nitric oxide nebulizer, prostacycline, surfactants, anti-inflammatory agents, antioxidants, phosphodiesterase inhibitors, immunonutrients, prostaglandin E1, anti-interleukins and inhibitors of thromboxanes and leucotriens

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