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SYNTHESIS OF NEW RING SYSTEM 6,7,8,9 TETRA HYDRO-5H-5-(2'- HYDROXY PHENYL)-2-(4'-SOME SUBSTITUTED BENZYLIDINE)-3-(4- NITROPHENYL AMINO) THIAZOLO QUINAZOLINE

Keywords: Quinazolin-2-thione , Thiazolo quinazoline , Benzylidine thiazolo quinazoline , Nitrophenyl amino thiazolo quinazoline.

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Abstract:

A convenient synthesis of the 6,7,8,9 tetra hydro-5H-5-(2'-hydroxy phenyl)-2-(4'-some substituted benzylidine)-3-(4-nitrophenyl amino) thiazolo quinazoline ring system is reported. Our syntheticapproach consisted of the annelation of a 4-hydroxy phenyl 3, 4, 5, 6, 7, 8-hexahydro quinazolin-2-thione moiety using chloroacetic acid as building blocks. The procedure needs the formation of the thiazolo quinazoline derivatives by substituted benzaldehyde and p-nitro aniline.

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