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COMPARATIVE EVALUATION OF EXTRACTS OF SENNA UNIFLORA FOR ANTI-INFLAMMATORY ACTIVITY

Keywords: Anti-inflammation , S. uniflora , Carrageenan , Plethysmograph.

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Abstract:

Aims and Objective: To study the benzene, alcohol and petroleum ether extract of Senna uniflora treatment against carrageenan induced paw oedema in albino rat model.Methods: The benzene, alcohol and petroleum ether extracts of Senna uniflora was given to paw oedema induced albino rats at doses administered intraperitoneally (I.P.) ranged from 50 to 200mg/kg body weight, which comparable with indomethacin (10 mg/kg) used as a reference drug.Results: The benzene and alcohol extracts administrated orally at dose of 200 mg/kg produced significant (P < 0.05) oedema inhibition when compared with indomethacin.Conclusion: The result suggested that benzene and alcohol extracts of Senna uniflora, showed significant inhibition on paw oedema albino rats. This study reveals the possible rationale for itsfolkloric use as an anti-inflammatory agent.

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