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ANTIGEN PROTEIN FROM XYLELLA FASTIDIOSA: NEW PARADIGM OF SYNTHETIC VACCINE DEVELOPMENT

Keywords: antigen protein , epitope , PSSM , SVM , MHC , peptide vaccine

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Abstract:

Xylella fastidiosa is a pathogenic bacterium that infects plants, causing a variety of diseases in over 100 plant species. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design and to increase the understanding of roles of the immune system in pathogenic diseases. Analysis shows MHC class II binding peptides of antigen protein from Xylella fastidiosa are important determinant for protection of host form infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 790 amino acids, which shows 782 nonamers.Binding ability prediction of antigen peptides to major histocompatibility complex (MHC) class I & IImolecules is important in vaccine development from Xylella fastidiosa.

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