Eupatorium odoratum Linn is found all over tropical Asia, western Africa and in parts of Australia. It is also found in Koraput district and extensively used traditionally by the tribal people as anti-inflammatory,analgesic, antiprotozoal agent’s e.t.c. Extraction of the leaves of the plant Eupatorium Odoratum using different solvents like petroleum ether, chloroform, ethanol and their analgesic activity studies has been envisage in this present research work. All the different extracts such as petroleum ether extract, chloroform extract and ethanolic extract has been subjected to analgesic activity studies. It has been found that onlyethanolic extract (P<0.01) shows maximum analgesic activity at a dose of 300 mg/kg whereas petroleum ether extract and chloroform extract shows moderate activity at the same dose when compared with thestandard drug aspirin.