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AN ION CHROMATOGRAPHIC METHOD FOR ESTIMATION OF METHANE SULPHONIC ACID IN GEMIFLOXACIN MESYLATE

Keywords: Gemifloxacin mesylate , conductivity detection , Ion chromatography , Methane sulphonic acid.

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Abstract:

The development and validation of an Ion chromatographic method for estimation of methane sulphonic acid in gemifloxacin mesylate drug substance was performed using acetone and buffer (1:9)as mobile phase and metrosep anion dual 2 as stationary phase at 0.5ml/min as flow rate. The analytes were monitored using suppressed conductivity detectors and linearity was obtained at the concentration range of 35.02 to 65.48 μg/ml and the correlation coefficient was found to be 0.9989.The recovery was found to be in the range of 103.53 to 116.30%w/w.

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