The main purpose of the present study was to develop matrix moderated transdermal patches of Pioglitazone HCl using various ratios of Ficus carica fruit mucilage. Physical parameters such as moisture content, moisture uptake, tensile strength, elongation and folding endurance were evaluated. The matrix type transdermal patches were prepared using Pioglitazone HCl with Ficus carica fruit mucilage by the solvent evaporation technique. The interactions between Pioglitazone Hcl and Ficus carica fruit mucilage and Pioglitazone HCl were performed. The transdermal patches were subjected to various physicochemical parameters like mechanical properties, permeation studies and skin irritation studies were performed. The prepared patches possessed satisfactory preformulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The nonionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a key role as permeability enhancers. The patches were found to seemingly free of potentially hazardous skin irritation. The experimental result shows that the release of drug from the patch was delayed in controlled manner as the proportion of Ficus carica fruit mucilage increased. It was concluded that Pioglitazone HCl can be developed as a transdermal patches with Ficus carica fruit mucilage.