The aim of the present study was to investigate the role of cerebellum in immunomodulation as cerebellum was thought traditionally to play an important role in voluntary motor activities. Rats weighing about 200-220 gm were subjected to bilateral electrolytic lesion of fastigial nucleus and following immune parameters were assessed- leucocyte migration inhibition test, foot pad thickness, antibody titre and estimation of cytokines – IL-2, IL-4 and IFN-γ respectively in immunized animals. Rats were divided in to three groups, namely control immunized, sham immunized and lesioned immunized groups. The sham group was strictly considered for evaluation of lesion effect as superficial structures during surgical procedure gets damaged and could also influence on immunomodulation. The significance was fixed at P<0.05. There was significant increase in migration index with concomitant decrease in foot pad thickness in bilateral lesion immunized groups. Significant alterations in cytokine levels were observed in lesion immunized groups when compared with its respective control groups.