The objective of the current study was to develop and validate simple and precise UV Spectrophotometric method for estimation of Diclofenac Sodium in the swab samples to validate cleaning procedure. The swabbing procedure was optimized in order to obtain a suitable recovery from stainless steel surface using Tex wipe polyurethane swab stick. Detection wavelength selected was 267 nm. The proposed method was validated in terms of Linearity, precision, accuracy, limit of detection and limit of quantitation. Linearity was studied over concentration range of 0.5 -3 μg / ml and correlation coefficient was found to be 0.999 for regression line. A recovery obtained was 94.58 %. LOD and LOQ for developed method were found to be 0.014715 μg/ml and 0.044592 μg/ml respectively.