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Synthesis of Di and Trisubstituted Oxazoles in Nonionic Liquid Under Catalyst Free Conditions

Keywords: α -haloketone , PEG 400 , Oxazoles , Urea , Phenyl urea.

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Abstract:

Catalyst free synthetic method was developed for di and tri substituted oxazoles from α -haloketones and urea/phenyl urea in Nonionic liquid like PEG 400.The reaction was carried out at ambient temperature and the product were obtained in excellent isolated yields (80-90%). Additionally, PEG could be recovered easily and was reused without evident loss in activity.

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