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Variety of functions and effects of kisspeptin

DOI: 10.7124/bc.000801

Keywords: kisspeptin , gonadotropin-releasing hormone , hypothalamic-pituitary-gonadal axis

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Abstract:

A brief review of the literature on the properties and efficacy of kisspeptin, in particular, for the regulation of en- docrine functions. The results of numerous experiments with kisspeptin in molecular biology, reproductive medicine and endocrinology, as well as the development of vaccines against malignant tumors, are analyzed. Kisspeptin is known to initiate a cascade of changes leading to the puberty. According to the reports, this peptide modifies the activity of glands that produce sex hormones, so it can be used in the treatment of diseases associated with the violation of puberty, especially amenorrhea in adolescent girls. The effect of this peptide is related to the activation of hypothalamic cells that produce GnRH, which regulates a level of gonadotropin-releasing hormone. Thus, kisspeptin can activate the reproductive system without violating the protective mechanisms of orga- nism. The in-depth research of kisspeptin effects on all parts of the hypothalamic-pituitary-gonadal axis is promising, as well as the investigation of neuron-glial interactions in the central nervous system under the influence of this peptide.

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