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The peculiarities of gene expression of medullary breast carcinoma tumor-associated antigensin different types of breast tumors

Keywords: medullary breast carcinoma , tumor-associated antigens , immunoreactivity

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Abstract:

Aim. To investigate gene expression profile of human medullary breast carcinoma’s tumor-associated antigens in different histological types of breast tumors. To analyze а correlation between alterations in gene expression level and induction of immune response against the corresponding antigens. Methods. Real-time polymerase chain reaction. Results. Differential gene expression profile of 6 (RAD50, HMGN2, RBPJ, PABPC4, BRAP, DEK) medullary breast carcinoma tumor-associated antigens have been revealed in breast tumors of different histological types. Correlation between changes in tumor-associated antigens gene expression level and induction of immune response has not been found. Conclusions. The genes of human medullary breast carcinoma tumor-associated antigens with differential expression profile in different histological types of breast tumors are potential diagnostic markers of breast cancer. Alteration of tumor-associated antigens gene expression level is not a prelude to an immune response against their corresponding protein products.

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