Salinity is one of the major factors limiting plant growth by imposing the osmotic, ion toxicity and oxidative stresses. The accumulation of osmoprotectants is a mechanism in which plants employ to protect tissue damages caused by salinity stress. The present study aimed to investigate the effect of two osmoprotectants (Sorbitol: Sor and Trehalose: Tre) on growth and physiology of rice (Oryza sativa L.) cvs. Khao Dawk Mali (KDML105; salt-sensitive) and Pokkali (PK: salt-tolerant) under NaCl stress. Under salt stress, KDML105 showed a significantly reduced growth and a large increase in the amount of hydrogen peroxide (H2O2), lipid peroxidation as indicated by Malondialdehyde (MDA) content and membrane Electrolyte Leakage (EL). The effects of salt were less severe in PK. Exogenously supplied Sor and Tre were able to enhance growth of salt-stressed KDML105 and alleviated the negative effects of salt by reducing H2O2 and MDA content. However, Sor and Tre did not have any beneficial effect on growth of PK plants. In some cases Sor worsened the salt-induced effects on lipid peroxidation and membrane damage. It can be concluded that exogenous Sor and Tre showed protective roles for salt-sensitive KDML105 but not salt-tolerant PK and the effects were more pronounced for Tre than Sor.