全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

Comparison of Clomiphene Citrate Plus Estradiol, with Tamoxifen Citrate Effects in Induction of Ovulation and Pregnancy in Poly Cystic Ovarian Syndrome Patients

Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering

Biodegradable Guar Gum Nanoparticles as Carrier for Tamoxifen Citrate in Treatment of Breast Cancer

Biotransformation of poly (epsilon-caprolactone) and poly (vinyl chloride) blend

Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation

Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation

Preparation and in vitro characterization of the transdermal drug delivery system containing tamoxifen citrate for breast cancer

Effect of administration of tamoxifen citrate on xanthine oxidase activity of liver during 3-methylcholanthrene induced carcinogenesis in female albino mice

IN-VITRO CYTOTOXICITY ANALYSIS OF TAMOXIFEN CITRATE LOADED CROSS-LINKED GUAR GUM NANOPARTICLES ON JURKAT (HUMAN T-CELL LEUKEMIA) CELL LINE

Gelatinized and nongelatinized corn starch/ poly(epsilon-caprolactone) blends: characterization by rheological, mechanical and morphological properties

更多...

Preparation and in vitro characterization of poly (epsilon-caprolactone)-based tamoxifen citrate-loaded cylindrical subdermal implant for breast cancer

Keywords: Breast cancer , cylindrical , implant subdermal , tamoxifen citrate

Full-Text   Cite this paper   Add to My Lib

Abstract:

In the present study cylindrical poly(epsilon-caprolactone) (PCL)-based biodegradable polymeric tamoxifen citrate-loaded subdermal implants were prepared by laboratory-based modified melt extrusion technique. The prepared implants were evaluated for their physicochemical parameters. Drug content in implants by high-performance liquid chromatographic (HPLC) method, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and scanning electron microscope (SEM) studies of tamoxifen citrate-loaded implants. Determination of in vitro hydrolytic degradation of polymeric and tamoxifen citrate-loaded implants and in vitro drug release was carried out by using indigenously developed dissolution apparatus. DSC and XRD studies proved that the drug is entrapped in the implant. The highest rate of hydrolytic degradation (weight loss) was observed in blank implants when compared to tamoxifen citrate-loaded implants. The studies proved that the developed method have potential in terms of industrial feasibility.

Full-Text

comments powered by Disqus