The aim of this study is investigate the effect of iron foliar applications at different growth stages on wheat yield and quality in sandy soil. Field experiment was carried out during 2008/2009 and 2009/2010 seasons at the Agriculture Faculty Farm-Sebha University, Libya to study the effect of foliar application by iron nutrient added at various growth stages on the grain and protein yields of some hard wheat varieties in sandy soil under sprinkler irrigation system. Results indicated that durum wheat varieties, iron foliar application, application time and their interaction had a significant (p≤0.05) effect in plant height, spike length, 1000-grain weight, grain weight spike-1, grain yield ha-1, grain protein content (%) and protein yield ha-1 in the tow growing season. Thus, Baney-Suief 2 variety gained the maximum values of all mentioned traits except grain protein content. Otherwise, Karim variety recorded maximum values of grain protein content in both seasons. Application of iron nutrient as foliar treatment by the rates from 200 to 600 ppm enhanced the all above traits as compared to control (untreated treatment) and the superiority in this respect to 600 ppm concentration. Moreover, foliar application at ZGS31 (Zadoks Growth Stage 31) epitasis from other times of application in all studied traits except grain protein content which registered from application at ZGS55. The highest values of grain and protein yields ha-1 (6850.1 and 917.9 kg ha-1 in first season for grain and protein yields, respectively being 6810.0 and 939.8 kg ha-1 in second season in the same order) were obtained from Baney-Suief 2 variety fertilized by 600 ppm of iron nutrient as foliar application at ZGS31.