Poverty in Nigeria has been on the increase with rural populace (predominantly farmers) most affected, living on less than 1 USD a day. The country is now ranked among the poorest nations in the world. Increased crop productivity and yields through sustainable agriculture is considered vital to any poverty alleviation strategies. With the current expanding populations in these regions, farmers faces tremendous challenges such as environmental sustainability, crop improvement through genetic engineering (genomics), biotic constraint and diseases coupled with local expertise and participations. New bio-approaches and technologies such as effective irrigation methods, proteomics technology, bio-control approaches and solar energy with storage techniques will offer hope to crop producers in northern Nigeria and at the same time resuscitating sustainable agriculture. System wide adoption and implementation of these new technologies will leads to the attainment of sustainable agriculture in Nigeria within the next few years. The involvement of commercial partners (stakeholders), to actively adopt and implement these new technologies is recommended.