The field trial was conducted to assess weed management practices in cotton at Students Farm, Sindh Agriculture University, Tandojam, Pakistan. The herbicides applied were: T1 = Dual Gold 960 EC @ 2.0 L ha-1 pre-emergence, T2 = Dual Gold 960 EC @ 2.5 L ha-1 pre-emergence, T3 = Stomp 330 EC @ 2.5. L ha-1 pre-emergence, T4 = Stomp 330 EC @ 3.75 L ha-1 pre-emergence, T4 = Hand weeding and T5 = Control. Weed flora after 71 days of sowing competing with experimental cotton were: Cyperus rotundus (40.03%), Portulaca oleraceae (17.77%), Cynodon dactylon (13.70%), Echinochlor columum (10.00%), Convolvulus arvensis (9.25%), Digeria arvensis (3.70%), Euphorbia hirta (1.85%), Cressia cretica (1.85%) and Chorchorus depressus (1.85%). Highest weed density (54.25 m2) and weed intensity (25.00 m2) were recorded in weedy (control) fields, while highest weed control percentage (74.07%) was observed in hand weeded plots. Among herbicide treatments, Dual Gold 960 EC @ 2.5 L ha-1 pre-emergence produced maximum weed control (56.66 %), followed by Dual Gold 960 EC @ 2.0 L ha-1 pre-emergence (36.66 %). Stomp 330 EC @ 3.75 L ha-1 pre-emergence resulted 33.33% weed control, while Stomp 330 EC @ 2.5 L ha-1 pre-emergence recorded 29.62% weed control. Mean cotton plant height (103.65 cm), monopodial branches (3.06) and sympodial branches (39.00) plant-1, productive bolls (32.3) plant-1 and seed cotton yield (3942.50 kg ha-1) were maximum in hand weeded plots. Among, herbicidal treatments, Dual Gold 960 EC @ 2.5 L ha-1 pre-emergence produced best results with 93.05 cm cotton plant height, 2.66 monopodial branches, 29.0 sympodial branches and 23.20 productive bolls plant-1 and seed cotton yield of 2992.50 kg ha-1. It was observed that weed control practices in cotton were more effective in controlling weeds and producing higher seed cotton yield, when integrated efforts which include manual weeding as well as use of herbicides are employed simultaneously. However, Dual Gold 960 EC @ 2.5 L ha-1 pre-emergence may be preferred for chemical control of weeds in cotton.