The study was undertaken to assess the effect of salinity and the anti-salinity agents on alleviating the adverse effects of salinity on growth and fruiting of Sewy, Zaghloul and Hayany date palm cultivars during 2010-2011 under Qena conditions. Ten years old, thirty palm trees of each cultivars, were evaluated to their tolerance to soil salinity and also to anti-salinity. The nine anti-salinity agents were sulphur, salicylic and citric acids, Effective Microorganism (EM), humic acid, compost enriched with actinomyces, filter mud, Uni-Sal and Cal-Mor. Moreover, the effect of these anti-salinity on leaf area, yield and fruit quality were also studied. Results revealed that date palm cultivars Sewy, Zaghloul and Hayany were tolerance to soil salinity, in descending order. However, Hayany date palm was highly sensitive to salinity than the other two cultivars and the Sewy cultivar was the most tolerant to soil salinity. Application of all anti-salinity agents was very effective in alleviating the adverse effect of salinity on the leaf area, yield and fruit quality as compared to the check treatment. The more effective five anti salinity agents were arranged in descending order as follows, Cal-Mor, Uni-Sal, citric acid, filter mud and compost enriched with actinomyces. Treated date palm with Cal-Mor at 150 mL/palm, Uni-Sal at 50 mL/palm or citric acid at 500 ppm twice considered to be preferable for avoiding the adverse effects of soil salinity on fruiting. Using of Cal-Mor on Sewy dates gave the highest value for vegetative growth and fruiting characters.