In order to determine urethral cytology findings of HPV in male patients of program Sexually Transmitted Infections of Lara state and identify the exposure to risk factors for transmission of this virus. We performed a descriptive sectional study, no probabilistic sample accidental of 94 individuals over 20 years of age during the period September-November 2009, also applied a structured questionnaire with closed questions, the data were processed using SPSS 11.5 for Windows, represented in absolute values and percentages. The frequency of positive findings consistent with HPV in urethral cytology was 14.89%. Among the risk factors studied with findings consistent with HPV urethral cytology found, history of sex with partner carriers of warts, cytology or biopsy positive for HPV with 28.57%, age of first intercourse less than 16 years with 19.05%, ≥ 10 sexual partners with 18.18%, occasional use of condoms, with 16.67%, 16.36% with smoking, contact with sex workers 10.00%. Patients with findings consistent with HPV cytology urethral papillomas showed 64.29%, as 62.50% with urethral cytology negative. It was concluded that the diagnosis of HPV in addition to the urethral smear necessary the application of other complementary research methods.