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Elevated serum levels of interleukin-17A in children with autism

DOI: 10.1186/1742-2094-9-158

Keywords: Autism, Autoimmunity, Childhood autism rating scale, IL-17A, T-helper 17

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Abstract:

Serum IL-17A levels were measured by ELISA in 45 children with autism and 40 matched healthy controls.Children with autism had significantly higher serum IL-17A levels than healthy controls (P <0.001), with increased serum levels of IL-17A found in 48.9% of the autism group. Patients with severe autism had significantly higher serum IL-17A levels than those with mild to moderate autism (P?=?0.01), and raised serum IL-17A levels were significantly more common in children with severe autism (67.9%) than in those with mild to moderate autism (17.6%), P?=?0.001.Serum IL-17A levels were raised in the group with autism, and the levels correlated significantly with the severity of autism. This is the first study to measure levels of IL-17A in relation to the severity of autism, to our knowledge. Further research, with a larger subject population, is warranted to determine whether the increase of serum IL-17A levels plasma has a pathogenic role in autism, and whether anti- IL-17A therapy could be useful

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