Cancer is a malignant disease that is characterized by rapid and uncontrolled formation of abnormal cells which may mass together to form a growth or tumour, or proliferate throughout the body. Next to heart disease cancer is a major killer of mankind. Present study aims at a preliminary phytochemical screening and anticancer evaluation of plumbago zeylanica Linn against Ehrlich Ascites Carcinoma in animal model. Results indicates that ethanolic extract of plumbago zeylanica Linn possess significant anticancer activity and also reduce elevated level of lipid peroxidation due to higher content of terpenoids and flavonoids. Thus ethanolic extract of plumbago zeylanica Linn could have vast therapeutic application against cancer.