The aim of this review is to highlight the inadequacies of the current control of African Trypanosomiasis in Nigeria and the need to strengthen the already integrated control approach. African Trypanosomiasis is one of the most devastating diseases of man and animals in Sub-Saharan African countries, Nigeria inclusive. Over the past century numerous methods of control have been developed yet the disease has proved very difficult to eradicate. Current methods to control the disease, in the absence of a vaccine, rely on the use of anti-trypanosomal drugs and vector control. In animals, an additional control method is the use of trypanotolerant breeds of livestock. Unfortunately, all of these methods have disadvantages and none has proved to be ideal. The public health importance of trypanosomiasis, has led to attempts to control the disease nationally and regionally with initiatives such as the Pan African Tsetse and Trypanosomosis Eradication Campaign (PATTEC) of the African union. At the Nigerian Institute for Trypanosomiasis Research (NITR), a combination of control methods is being used for research development and control efforts against the disease. However, diminishing funding for research development and control activities against the disease has hindered this approach. Hence there is a great need to strengthen these integrated approaches for more effective control of trypanosomiasis. Strengthening intersectoral and inter-agency collaboration is greatly advocated in the fight against trypanosomiasis, in order to improve the effectiveness and efficiency of control, as well as enhance the prospect of sustainability and food security as supported by PATTEC. Hence, further fostering the existing relationship with PATEC in a bid towards the eradication of trypanosomiasis from Nigeria.