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Susceptibilities of ESBL-Producing Enterobacteriaeceae To Ertapenem, Meropenem and Piperacillin-Tazobactam

Keywords: Ertapenem , ESBL , Meropenem , E.coli , K .pneumonia

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Abstract:

Objectives: The susceptibilities of ESBL-producing E.coli and K. pneumoniae to ertapenem, meropenem and piperacillin-tazobactam.53 strains of E.coli and K. pneumoniae were studied. Methods: They were originally resistant to ceftazidine. Minimum inhibitory concentration of the strains towards ertapenem, meropenem and piperacillin-tazobactam were determined by Vitek-2 compact system. Results: The MICs of all ertapenem and meropenem for all isolates were <0.5 mg/ml and <0.25 mg/ml respectively and MIC of piperacillin-tazobactam was between 4 to 16 mg/ml. ESBL-producing organisms were more susceptible to ertapenem and meropenem. They were susceptible to piperacillin-tazobactam thus in our hospital ertapenem, meropenem and piperacillin-tazobactam are drugs of choice for them. [National J of Med Res 2012; 2(2.000): 223-225]

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