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Neoadjuvant sorafenib combined with gemcitabine plus oxaliplatin in advanced hepatocellular carcinoma

DOI: 10.3748/wjg.v17.i17.2255

Keywords: Hepatocellular carcinoma , Gemcitabine , Oxaliplatin , Sorafenib , Neoadjuvant therapy

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This paper reports the first case of a patient with hepatocellular carcinoma with lymph node metastasis treated by sorafenib combined with gemcitabine plus oxaliplatin, with a partial response and normalization of α fetoprotein, which allowed curative surgery. The potential synergy between these three drugs needs to be confirmed, and is currently being investigated in a randomized phase II trial.


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