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Neuroglobin-overexpression reduces traumatic brain lesion size in mice

DOI: 10.1186/1471-2202-13-67

Keywords: Neuroglobin, Neuroprotection, Controlled cortical impact, Oxidative stress, Traumatic brain injury

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Abstract:

Both Ngb over-expression transgenic (Ngb-Tg) and wild-type (WT) control mice were subjected to TBI induced by a controlled cortical impact (CCI) device. TBI significantly increased Ngb expression in the brains of both WT and Ngb-Tg mice, but Ngb-Tg mice had significantly higher Ngb protein levels at the pre-injury baseline and post-TBI. Production of oxidative tissue damage biomarker 3NT in the brain was significantly reduced in Ngb-Tg mice compared to WT controls at 6 hours after TBI. The traumatic brain lesion volume was significantly reduced in Ngb Tg mice compared to WT mice at 3 weeks after TBI; however, there were no significant differences in the recovery of sensorimotor and spatial memory functional deficits between Ngb-Tg and WT control mice for up to 3 weeks after TBI.Ngb over-expression reduced traumatic lesion volume, which might partially be achieved by decreasing oxidative stress.

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