According to the characteristics of beer brewing wastewater, Up-flow Anaerobic Sludge Bed and Membrane Bio-Reactor integrated technics (UASB+MBR) was applied. This paper investigated various operating parameters during the process of wastewater treatment in MBRs. The sludge loading and the membrane fouling were analyzed by detecting the sludge concentration and sludge characteristics. The results showed that when CODCr, NH4-N, T-P and T-N concentrations of the feed water were 500~1000mg/L, 20~30mg/L, 0.6~14mg/L and 19.5~41.1mg/L, respectively, it got some conclusions in the process.(1)The CODCr , NH4-N , T-P and T-N of MBR effluent could reduce to 40mg/L, 2.3mg/L , 0.3mg/L, 3mg/L, respectively. The quality of the effluent water in this system met the reuse of urban recycling water—Water quality standard landscaping water according to GB/T18921-2002; (2)The DO of the aerobic pool should be controlled at the range of 2~4mg/L, which could increase the removing efficiency of the NH4-N. (3)Appropriate adjustments to the volume of sludge and maintain the sludge concentration of membrane pool at 6~8g /L, which could reduce the velocity of membrane fouling. (4) With 1000mg/L of sodium hypochlorite and 2000mg/L hydrochloric acid alternate cleaning, the recovery of membrane flux can maintain above 95%.