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Simultaneous spectrophotometric determination of atorvastatin calcium and amlodipine besylate in tablets

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Abstract:

Two simple, accurate and precise methods for simultaneous estimation of atorvastatin calcium and amlodipine besylate in combined dosage form have been described. First method employs formation and solving of simultaneous equations using 245 nm and 363 nm as two analytical wavelengths. Second is dual wavelength method, which uses the difference of absorbance value at 259.9 nm and 354 nm for estimation of atorvastatin calcium and absorbance at 363 nm for amlodipine besylate. Fifty percent methanol was used as solvent, in which atorvastatin calcium and amlodipine besylate shows linearity in the range of 0-40 μg/ml and 0-20 μg/ml, respectively. Standard deviation was < 1.5 in the assay of tablets. Methods were validated as per ICH norms and accuracy, precision, repeatability and robustness was found to be with in the acceptable limit.

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