Phytochemicals presents in plants probably explain the various uses of plants for traditional medicine. Inthis study Kigelia Africana fruit was selected for assessing the level of various Phytochemicals, enzymaticand non- enzymatic antioxidants & antimicrobial activity. Fruits of the plant taken, dried, grind to powderand then aqueous and ethanolic extracts were prepared. Antimicrobial activity of these extracts was thenstudied using agar well plate method. Results of the study showed that aqueous extract of Kigelia Africanahave significant amount of phytochemicals & antioxidant enzymes so useful to prevent chronic diseasesrelated to oxidative stress in human body. Antimicrobial activity of aqueous extract was more than theethanolic extract.