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Molecular oncogenesis from a microRNA perspective

Keywords: apoptosis , cancer , miRNA , oncogenesis , translational repression

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Abstract:

MicroRNAs (miRNAs) are a class of small, non-protein-coding RNA molecules that negatively regulate gene expression primarily through post-transcriptional repression. They have been implicated in the regulation of a variety of fundamental cellular and physiological processes relevant to cancer development. By acting as oncogenes ('oncomirs') or tumour suppressors, miRNAs play a crucial role in oncogenesis and cellular transformation. This review highlights the association of miRNAs with a number of cancer types and their mode of action, where available, will also be discussed.

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