Objective: (1) To find out the result of drug to what extent it reduces the need for sedatives. (2) Tocompare the results with other treatment. Study Design: Prospective analytical. Setting: Tetanus ward D.H.Q.Hospital Faisalabad/ Subjects & Methods: Six patients with Tetanus were studied Inclusion Criteria: Adultmale&females suffering from Tetanus. Exclusion Criteria: Patient with known peptic ulcer disease and benignprostatic hyperplasia. Results: Six patients were given trial of Atropine infusions with continuous monitoring of pulseand blood pressure. Patients were provided conventional sedation along with Atropine infusion. The requirement ofsedative drug was significantly reduced when the dose of Atropine was gradually increased. The patients remainedmentally alert with marked reduction in muscle spasm, convulsion ,no element of anxiety or agitation. Respiratoryproblems were minimized. One female expired probably due to septic shock from induced abortion. Conclusion:Atropine sulphate is cheaper drug ,easily available ,short half life, minimal side effect and much important in developingand under developed countries where ICU facilities are not available.